Correlation between quantitative and qualitative assessments of white matter hyperintensities in patients from a multicentric memory clinic population

Background White matter hyperintensities (WMH) can be visualized as abnormal T2 signal in the periventricular, deep and subcortical white on Magnetic Resonance Imaging (MRI). WMH increase with age are associated stroke, cognitive decline dementia. The most common visual rating scale used to assess clinical setting is Fazekas (Fazekas et al., 1987). current study investigated relationship between volume (expressed a % of intra-cranial (ICV)) calculated using an automated method included QyScore® medical device, scores multicentric memory clinic population at baseline. Method 1959 participants from MEMENTO cohort (Age 71.02 +/- 8.61, 1218 Female, MMSE 27.95 1.91) had 3DT1 FLAIR MRI scans analyzed QyScore®, FDA-approved CE-marked image analysis software. 814 amyloid status CSF or PET, which 216 were Amyloid+. volumes reported mL, corrected for %ICV. Correlation (DWM) quantitative measurements was ascertained by Spearman’s rank correlation. Result There significant positive correlation DWM %ICV (0.76 p<0.001) total sample, (0.81 negative (0.72 patients. also strong when separated diagnosis: patients Subjective Cognitive Complaint (SCC, N = 305, AGE: 69.87 8.03, 197 female, MMSE: 28.86 1.17) MCI (N 1638, Age: 71.2 8.69, 1014 27.8 1.95) presented correlated (0.66 p<0.001 SCC; 0.77 MCI). Conclusion quantification ICV-corrected well-correlated scores. Considering that time consuming suffers intra inter-operator variability, assessment load provided may improve impairment.